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16S rRNA RefSeq: V15.22    Genomic RefSeq: V9.15
Genus: Aggregatibacter
Lineage: Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter
Overview: Bacteria of genus Aggregatibacter are moderately abundant in the mouth, making up 2% or less at most oral sites except for the tongue dorsum where they are in very low abundance. Members of the genera Haemophilus and Aggregatibacter are closely related and not always cleanly distinguished using short fragments of the 16S ribosomal RNA gene.

Ecological role/importance in health and disease: The Aggregatibacter species most abundant in the healthy mouth are A. aphrophilus, A. paraphrophilus, A. segnis, and the unnamed A. sp. HMT 458. The species A. actinomycetemcomitans is associated with periodontitis, including aggressive periodontitis, and was part of the "green complex" of Socransky et al. (1998).

Aggregatibacter Image
Corncob structures in dental plaque with a "cob" formed by Corynebacterium matruchotii (magenta) and "kernels" formed by Streptococcus cristatus or the S. mitis/oralis group (green) and Porphyromonas species (blue). The orange cells surrounding the streptococci are Aggregatibacter or Haemophilus spp.
See Mark Welch et al. 2016
eHOMD Taxonomy
LifeCellular Organisms
 DomainBacteria (788) Abundance
  PhylumProteobacteria (141) Abundance
   ClassGammaproteobacteria (53) Abundance
    OrderPasteurellales (21) Abundance
     FamilyPasteurellaceae (21) Abundance
      GenusAggregatibacter (9) Abundance
       Species       Aggregatibacter actinomycetemcomitans (HMT-531) Abundance
       Aggregatibacter aphrophilus (HMT-545) Abundance
       Aggregatibacter paraphrophilus (HMT-720) Abundance
       Aggregatibacter segnis (HMT-762) Abundance
       Aggregatibacter sp._HMT_458 (HMT-458) Abundance
       Aggregatibacter sp._HMT_512 (HMT-512) Abundance
       Aggregatibacter sp._HMT_513 (HMT-513) Abundance
       Aggregatibacter sp._HMT_898 (HMT-898) Abundance
       Aggregatibacter sp._HMT_949 (HMT-949) Abundance